Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension

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Bedtime dosing of antihypertensive medications: systematic review and consensus statement : International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension

Stergiou, George (author): Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece

Brunström, Mattias (author): Umeå universitet,Avdelningen för medicin

MacDonald, Thomas (author): Director of MEMO Research, Ninewells Hospital & Medical School, University of Dundee, United Kingdom

Kyriakoulis, Konstantinos G. (author): Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece

Bursztyn, Michael (author): Hypertension Clinic, Hadassah-Hebrew University Medical Center, Faculty of Medicine, Hadassah-Hebrew University School of Medicine, Department of Medicine D, Beilinson Hospital, Israel

Khan, Nadia (author): Department of Medicine, University of British Columbia, Center for Health Evaluation and Outcomes Sciences, Vancouver, Canada

Bakris, George (author): Department of Medicine, University of Chicago Medicine, IL, Chicago, United States

Kollias, Anastasios (author): Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece

Menti, Ariadni (author): Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece

Muntner, Paul (author): School of Public Health, University of Alabama at Birmingham, AL, Birmingham, United States

Orias, Marcelo (author): Yale University, CT, New Haven, United States

Poulter, Neil (author): Imperial Clinical Trials Unit, School of Public Health, Imperial College London, Stadium House, London, United Kingdom

Shimbo, Daichi (author): Columbia Hypertension Center and Lab, Department of Medicine, Columbia University Irving Medical Center, NY, United States

Williams, Bryan (author): Institute of Cardiovascular Science, University College London, London, United Kingdom

Adeoye, Abiodun Moshood (author): Cardiovascular Genetics and Genomic Research Unit, Institute of Cardiovascular Diseases, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria

Damasceno, Albertino (author): Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique

Korostovtseva, Lyudmila (author): Almazov National Medical Research Centre, St Petersburg, Russian Federation

Li, Yan (author): Department of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Lab of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

Muxfeldt, Elizabeth (author): , Universidade Federal do Rio de Janeiro - Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil

Zhang, Yuqing (author): Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Mancia, Giuseppe (author): University of Milano-Bicocca, Milan, Italy

Kreutz, Reinhold (author): Charité - Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany

Tomaszewski, Maciej (author): Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester; Manchester Heart Centre and Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom

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Lippincott Williams & Wilkins, 2022
2022
English.
In: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598. ; 40:10, s. 1847-1858

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Research review (peer-reviewed)

Abstract Subject headings

Antihypertensive drug therapy is one of the most efficient medical interventions for preventing disability and death globally. Most of the evidence supporting its benefits has been derived from outcome trials with morning dosing of medications. Accumulating evidence suggests an adverse prognosis associated with night-time hypertension, nondipping blood pressure (BP) profile and morning BP surge, with increased incidence of cardiovascular events during the first few morning hours. These observations provide justification for complete 24-h BP control as being the primary goal of antihypertensive treatment. Bedtime administration of antihypertensive drugs has also been proposed as a potentially more effective treatment strategy than morning administration. This Position Paper by the International Society of Hypertension reviewed the published evidence on the clinical relevance of the diurnal variation in BP and the timing of antihypertensive drug treatment, aiming to provide consensus recommendations for clinical practice. Eight published outcome hypertension studies involved bedtime dosing of antihypertensive drugs, and all had major methodological and/or other flaws and a high risk of bias in testing the impact of bedtime compared to morning treatment. Three ongoing, well designed, prospective, randomized controlled outcome trials are expected to provide high-quality data on the efficacy and safety of evening or bedtime versus morning drug dosing. Until that information is available, preferred use of bedtime drug dosing of antihypertensive drugs should not be routinely recommended in clinical practice. Complete 24-h control of BP should be targeted using readily available, long-acting antihypertensive medications as monotherapy or combinations administered in a single morning dose.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Keyword

ambulatory blood pressure monitoring
antihypertensive drugs
bedtime administration
chronotherapy
dipper
nocturnal blood pressure
systematic review

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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